{"id":1367,"date":"2025-09-17T15:43:41","date_gmt":"2025-09-17T15:43:41","guid":{"rendered":"https:\/\/medi-pharm.sk\/publikacie"},"modified":"2025-11-23T12:00:59","modified_gmt":"2025-11-23T12:00:59","slug":"publikacie","status":"publish","type":"page","link":"https:\/\/medi-pharm.sk\/sk\/publikacie","title":{"rendered":"Publik\u00e1cie"},"content":{"rendered":"\t\t
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Publik\u00e1cie<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\tPamidron\u00e1t a kyselina zoledr\u00f3nov\u00e1: porovn\u00e1vac\u00ed preh\u013ead intraven\u00f3znych bisfosfon\u00e1tov obsahuj\u00facich dus\u00edk\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t
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Bisfosfon\u00e1ty dlhodobo predstavuj\u00fa v\u00fdznamn\u00fa terapeutick\u00fa triedu v lie\u010dbe ochoren\u00ed charakterizovan\u00fdch nadmernou resorpciou kost\u00ed. Od ich zavedenia v 70. rokoch 20. storo\u010dia transformovali lie\u010dbu metabolick\u00fdch ochoren\u00ed kost\u00ed, osteopor\u00f3zy, hyperkalc\u00e9mie s\u00favisiacej so<\/p>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\n\t\t\t23 novembra, 2025\t\t<\/span>\n\t\t\t\t\n\t\t\t3:11 pm\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\tStrat\u00e9gie formul\u00e1cie a stability pre nimodip\u00edn: od in\u017einierstva \u010dast\u00edc po v\u00fdrobu pod\u013ea SVP\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t
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Nimodip\u00edn je dihydropyrid\u00ednov\u00fd blok\u00e1tor v\u00e1pnikov\u00fdch kan\u00e1lov s v\u00fdraznou cerebrovaskul\u00e1rnou selektivitou, klinicky pou\u017e\u00edvan\u00fd na ochranu mozgu pred ischemick\u00fdm po\u0161koden\u00edm prostredn\u00edctvom preferen\u010dn\u00e9ho uvo\u013enenia hladk\u00e9ho svalstva mozgov\u00fdch art\u00e9ri\u00ed pri obmedzen\u00ed syst\u00e9movej hypotenzie. Jeho<\/p>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\n\t\t\t15 okt\u00f3bra, 2025\t\t<\/span>\n\t\t\t\t\n\t\t\t9:39 am\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\tProtam\u00edn sulf\u00e1t v E\u00da: analytick\u00e1 valid\u00e1cia, kontrola hotov\u00e9ho lieku a regula\u010dn\u00e9 cesty\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t
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Protam\u00edn sulf\u00e1t je polypeptid bohat\u00fd na argin\u00edn, pou\u017e\u00edvan\u00fd ako klinick\u00e9 antidotum hepar\u00ednu a ako funk\u010dn\u00e1 pomocn\u00e1 l\u00e1tka vo vybran\u00fdch parenter\u00e1lnych a kombinovan\u00fdch produktoch. Jeho mechanizmus \u00fa\u010dinku spo\u010d\u00edva v elektrostatickej v\u00e4zbe<\/p>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\n\t\t\t8 okt\u00f3bra, 2025\t\t<\/span>\n\t\t\t\t\n\t\t\t6:30 pm\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\tOd racem\u00e1tu k jedn\u00e9mu enantiom\u00e9ru\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t
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Farmakokinetick\u00e9 rozdiely, klinick\u00fd kontext a procesn\u00e1 expert\u00edza MediPharm \u017dal\u00fado\u010dn\u00e1 kyselina je u\u017e dlho uzn\u00e1van\u00e1 ako k\u013e\u00fa\u010dov\u00fd faktor vo fyziol\u00f3gii hornej \u010dasti gastrointestin\u00e1lneho traktu, pri\u010dom zohr\u00e1va z\u00e1sadn\u00fa \u00falohu pri tr\u00e1ven\u00ed bielkov\u00edn,<\/p>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\n\t\t\t27 septembra, 2025\t\t<\/span>\n\t\t\t\t\n\t\t\t9:45 am\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\tLyofiliz\u00e1cia pre biologick\u00e9 a parenter\u00e1lne formul\u00e1cie: v\u00fdvoj, n\u00e1vrh cyklu a implement\u00e1cia GMP\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t
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Lyofiliz\u00e1cia, alebo mrazov\u00e9 su\u0161enie, je k\u013e\u00fa\u010dov\u00e1 stabiliza\u010dn\u00e1 technol\u00f3gia pre biologick\u00e9 a labiln\u00e9 parenter\u00e1lne formul\u00e1cie, ktor\u00e1 premie\u0148a roztok na pevn\u00e9 skupenstvo postupn\u00fdm zmrazen\u00edm, sublim\u00e1ciou \u013eadu po\u010das prim\u00e1rneho su\u0161enia a odstr\u00e1nen\u00edm viazanej<\/p>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\n\t\t\t27 septembra, 2025\t\t<\/span>\n\t\t\t\t\n\t\t\t9:29 am\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\tNukleozidov\u00e9 a nukleotidov\u00e9 anal\u00f3gy: ch\u00e9mia, v\u00fdroba a CMC strat\u00e9gie pre regula\u010dn\u00e9 podanie\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t
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Vedeck\u00e9 pozadie a terapeutick\u00fd kontext Nukleozidy, pozost\u00e1vaj\u00face z dus\u00edkatej b\u00e1zy kovalentne viazanej na rib\u00f3zu alebo deoxyrib\u00f3zu, s\u00fa z\u00e1kladn\u00fdmi prekurzormi pre biosynt\u00e9zu nukleov\u00fdch kysel\u00edn a tvoria chemick\u00e9 jadro oligonukleotidov\u00fdch monom\u00e9rov pou\u017e\u00edvan\u00fdch<\/p>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\n\t\t\t15 septembra, 2025\t\t<\/span>\n\t\t\t\t\n\t\t\t12:37 pm\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Publik\u00e1cie<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1367","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medi-pharm.sk\/sk\/wp-json\/wp\/v2\/pages\/1367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medi-pharm.sk\/sk\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medi-pharm.sk\/sk\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medi-pharm.sk\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medi-pharm.sk\/sk\/wp-json\/wp\/v2\/comments?post=1367"}],"version-history":[{"count":8,"href":"https:\/\/medi-pharm.sk\/sk\/wp-json\/wp\/v2\/pages\/1367\/revisions"}],"predecessor-version":[{"id":1568,"href":"https:\/\/medi-pharm.sk\/sk\/wp-json\/wp\/v2\/pages\/1367\/revisions\/1568"}],"wp:attachment":[{"href":"https:\/\/medi-pharm.sk\/sk\/wp-json\/wp\/v2\/media?parent=1367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}